Physio-biochemical Alterations in Trypanosoma Infected Dog
نویسندگان
چکیده
Trypanosomosis is a disease caused by a flagellate protozoan known as Trypanosoma evansi, transmitted by hematophagous insects. It parasites showed a large diversity of mammalian hosts. Dogs may show clinical changes such as weight loss, progressive weakness, anorexia, anemia, intermittent fever, conjunctivitis, swelling of limbs and increased of superficial lymph nodes. Treatment of trypanosomosis relies on the use of diminazene aceturate which is effective for the treatment of disease in infected animals. However, a single dose of drug are not effective for horses, mules and dogs, since drug neither cross the blood-brain barrier or has insufficient doses to control the T. evansi infection. Therefore, the present study aimed to report the curative efficacy of a new therapeutic protocol, based on diminazene aceturate, for dogs infected with T evansi. In the present study, Trypanosoma infection is reported in a male Labrador dog of three years age at TVCC, Goregaon, Mumbai. Clinical signs and symptoms of infection are recorded. Confirmation of case was done by microscopic examination of Trypanosoma organism in thick blood smear and serum biochemistry. Furthermore, their effect on certain hematological parameters was studied and concluded that there was decrease of hemoglobin (Hb) concentration and packed cell volume (PCV) and Total protein while erythrocytes sedimentation rate (ESR), SGOT and SGPT levels were increased in the infected dog.
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